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Вот свежая статья про операции у больных с переломами проксимального отдела бедра, принимавших плавикс, аспирин, варфарин... Обращает внимание даже не результат, что Clopidogrel only versus aspirin versus both aspirin and clopidogrel, versus no anticoagulant versus warfarin showed no significant differences in estimated blood loss, transfusion requirement, final blood count, bleeding or perioperative complications, or mortality (Плавикс vs аспирин vs аспирин+плавикс vs без антикоагулянтов vs варфарин показали отсутствие значиых отличий по оцененной кровопотере, трансфузионным потребностям, окончательным показателям крови, кровотечениию, периоперационым осложнениям и летальности). - а что многие десятки пациентов брали без отмены и выжидания в несколько дней, да и оперировали! http://www.ncbi.nlm.nih.gov/pubmed/22441640 ==================================J Orthop Trauma. 2012 Mar 21. [Epub ahead of print] The Effects of Clopidogrel (Plavix) and Other Oral Anticoagulants on Early Hip Fracture Surgery. Collinge CA, Kelly KC, Little B, Weaver T, Schuster RD. Source *Harris Methodist Fort Worth Hospital/John Peter Smith Orthopedic Surgery Residency, Fort Worth, TX †Division of Pharmacy, Dallas Veterans Affairs Medical Center, Dallas, TX ‡Tarleton State University, Stephenville, TX §Orthopedic Specialty Associates, Fort Worth, TX ‖Cook's Childrens's Hospital, Fort Worth, TX. Abstract OBJECTIVE: Risk for bleeding complications during and after early hip fracture surgery for patients taking clopidogrel and other anticoagulants have not been defined. The purpose of this study is to assess the perioperative bleeding risks and clinical outcome after early hip fracture surgery performed on patients taking clopidogrel (Plavix) and other oral anticoagulants. DESIGN: Study design is a retrospective cohort analysis using data extracted from hospital records and state death records. SETTING: Regional medical center (level II trauma). METHODS: Data for 1118 patients ≥60 years of age who had surgical treatment for a hip fracture between 2004 and 2008 were reviewed. Eighty-two patients undergoing late surgery (>3 days after admission) were excluded. Patients taking clopidogrel were compared against those not taking clopidogrel. In addition, patients taking clopidogrel only were compared against cohorts of patients taking both clopidogrel and aspirin, aspirin only, warfarin only, or no anticoagulant. RESULTS: Seventy-four of 1036 patients (7%) were taking clopidogrel, although control groups included 253 patients on aspirin alone, 90 patients on warfarin, and 619 taking no anticoagulants. No significant differences were noted between patients taking clopidogrel and those not taking clopidogrel in estimated blood loss, transfusion requirement, final blood count, hematoma evacuation, hospital length of stay (LOS), or mortality while in hospital or at 1 year. A higher American Society of Anesthesiologists score was seen in the clopidogrel and warfarin groups (P = 0.05 each), increased LOS in the clopidogrel group (P = 0.05), and higher rate of deep vein thrombosis seen in those patients taking warfarin (P = 0.05). Clopidogrel only versus aspirin versus both aspirin and clopidogrel, versus no anticoagulant versus warfarin showed no significant differences in estimated blood loss, transfusion requirement, final blood count, bleeding or perioperative complications, or mortality. CONCLUSIONS: Patients undergoing early hip fracture surgery who are taking clopidogrel, aspirin, or warfarin (with regulated international normalized ratio) are not at substantially increased risk for bleeding, bleeding complications, or mortality. Comorbidities and American Society of Anesthesiologists scores were significantly higher in the clopidogrel group, which may have resulted in the increased postoperative LOS in this group. PMID: 22441640 [PubMed - as supplied by publisher] ================================== < | >
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The Effects of Clopidogrel (Plavix) and Other Oral Anticoagulants on Early Hip Fracture Surgery
