[Ortho] ScienceDirect Alert: Bone, Vol. 42, Supp. 1, 2008
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Вт Мар 11 15:31:26 YEKT 2008
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* Bone
Volume 42, Supplement 1, Pages S1-S116 (March 2008)
IBMS DAVOS WORKSHOPS: BONE BIOLOGY & THERAPEUTICS, IBMS DAVOS WORKSHOPS: BONE BIOLOGY & THERAPEUTICS
Davos, Switzerland
09-14 March 2008
IBMS is grateful to its sponsors for their support of the IBMS Davos Workshops: Bone Biology & Therapeutics: The Alliance for Better Bone Health, Amgen, Inc., F. Hoffmann-La Roche LTD, Hologic, Inc., Novartis Oncology, and Merck & Co., Inc.
http://www.sciencedirect.com/science/issue/4987-2008-999579999.8998-682868
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TABLE OF CONTENTS
1) Editorial Board
Pages i-ii
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2) Committees and Contact Information
Pages S1-S4
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3) Conference Schedule
Pages S5-S16
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4) Platelet-released supernatant increases the plasminogen activation capacity of human bone marrow stromal cells
Page S17
Hermann Agis, Barbara Kandler, Michael B. Fischer, Georg Watzek and Reinhard Gruber
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5) The effects of dexamethasone on PTHrp and PTH1R-receptor expression in human mesenchymal stem cells and osteoblasts
Page S17
Mikael Ahlstrom, Minna Pekkinen and Christel Lamberg-Allardt
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6) Scaffold design and optimization: the use of endothelial progenitor cells in vitro and in vivo
Pages S17-S18
Jacqueline Alblas, Ruth Geuze, Natalja Fedorovich, Diyar Delawi, Yvonne van der Helm, Rene Haverslag, Fiona Wegman, Daphne van Geemen, Ab Verbout and Wouter Dhert
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7) Flow perfusion improves mineralization and maintains uniform cellular distribution in thick 3D scaffolds
Page S18
Alexander C. Allori, Alexander M. Sailon, Clarence D. Lin, Elizabeth Clark, John L. Ricci, Cornelia Vasiliu, James E. Smay and Stephen M. Warren
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8) Lack of oxytocin retards osteoblast differentiation and bone formation
Pages S18-S19
Graziana Colaianni, Roberto Tamma, Adriana Di Benedetto, Claudia Camerino, Giovanni Greco, Nicola Patano, Maurizio Strippoli, Rosaria Vergari, Li Sun, Mone Zaidi and Alberta Zallone
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9) Lactoferrin, a regulator of bone — mechanisms of action
Page S19
Jillian Cornish, Dorit Naot, Ashika Chhana and Ian R. Reid
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10) Tumor necrosis factor-alpha — a stimulator and an inhibitor of osteoclast development in vitro
Pages S19-S20
Silvia Dolder, Tina Dauwalder and Willy Hofstetter
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11) TGF2 beta protects osteoblast apoptosis induced by mechanical unloading by targeting PI3K/Akt/Bad signaling in vivo
Page S20
Cecilie Dufour, Xavier Holy and Pierre J. Marie
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12) Inactivation of the Integrin-Linked Kinase (ILK) in osteoblasts increases mineralization
Pages S20-S21
Jad El-Hoss, Alice Arabian, Shoukat Dedhar and Rene St-Arnaud
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13) Investigating the role of the extracellular matrix on differentiation of human mesenchymal stem cells and MC3T3 cells
Page S21
Hugo Fernandes, Koen Dechering, Eugene van Someren, Clemens van Blitterswijk and Jan de Boer
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14) Creatine supplementation stimulates collagen type I and osteoprotegerin secretion of healthy and osoteopenic primary human osteoblast-like cells in vitro
Pages S21-S22
Isabel Gerber, Hanswerner Gerber, Claudio Dora, Daniel Uebelhart and Theo Wallimann
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15) Encapsulation of osteoprogenitor and endothelial cell co-cultures for bone tissue engineering application
Page S22
Maritie Grellier, Silvia J. Bidarra, Reine Bareille, Jean-Christophe Fricain, Pedro L. Granja, Mario A. Barbosa and Joelle Amedee
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16) Bone cell responsiveness to growth and differentiation factors under hypoxia in vitro
Pages S22-S23
Reinhard Gruber, Barbara Kandler, Hermann Agis, Michael B. Fischer and Georg Watzek
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17) Thrombospondins influence endocortical bone mass by regulating the pool of available marrow osteoprogenitors
Page S23
Kurt D. Hankenson, Hailu Shitaye, Steven M. Tommasini, Michael Wang and Karl J. Jepsen
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18) Nitric oxide synthesis in eNOS null mice in response to fluid shear stress: A slow story
Page S23
Carmen Huesa, Astrid Bakker, Jenneke Klein-Nulend, Richard M. Aspden and Miep H. Helfrich
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19) ERK1/2 and Fra-1 mediate phosphate-dependent stimulation of matrix Gla protein expression in osteoblasts
Pages S23-S24
Marion Julien, Solmaz Khoshniat, Aline Lacreusette, Martial Masson, Aline Bozec, Erwin Wagner, Pierre Weiss, David Magne and Jerome Guicheux
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20) Calcium is required for phosphate-dependent stimulation of MGP and OPN expression in osteoblasts
Page S24
Solmaz Khoshniat, Marion Julien, Laurent Beck, Marc Petit, Thierry Rouillon, Martial Masson, Maithe Gatius, Pierre Weiss and Jerome Guicheux
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21) Regulation of mitogen-activated protein kinase phosphatase-1 by PTH/PTHrP involves cAMP and PKC pathways in differentiated osteoblasts
Pages S24-S25
Rola Kolailat, Glenda J. Pettway, Laurie K. McCauley, Abdul B. Abou-Samra and Nabanita S. Datta
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22) Runx2 and HDAC3 mediated-repression is relieved in differentiating human osteoblast cells to allow high BSP expression
Page S25
Virginie Lamour, Cedric Detry, Vincent Castronovo and Akeila Bellahcene
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23) Different protein kinase C isozymes exert opposing effects on osteogenesis of human mesenchymal stem cells
Page S25
Jun Liu, Clemens A. van Blitterswijk and Jan de Boer
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24) Stage-specific subsets of perichondrial osteoblasts differentially relate to endothelium and bone and display different destinations in development
Pages S25-S26
Christa Maes, Tatsuya Kobayashi, Martin K. Selig, Sanford I. Roth and Henry M. Kronenberg
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25) Hedgehog signaling in mature osteoblasts regulates bone formation and resorption by controlling PTHrP and RANKL expression
Page S26
Kinglun Kingston Mak and Yingzi Yang
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26) A 3D culture system to investigate osteocyte control of osteoblasts
Pages S26-S27
Deborah J. Mason, Christopher M. Dillingham, Bronwen A. Evans, Karen Brakspear and Jim R. Ralphs
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27) IGF-I secreted from osteoblasts as a major chemotactic factor for osteoblasts
Page S27
Manando Nakasaki, Hideki Yoshikawa and Kazuyuki Itoh
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28) Risk factors affecting implant and periodontal tissues reactions
Page S27
Victor Palarie and Constantin Bicer
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29) Collagen/calcium phosphate and bone marrow aspirate in new bone formation at the mandible jaw
Pages S27-S28
Victor P. Palarie
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30) Bone implant complex interaction
Page S28
Victor Palarie
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31) Snail, a transcription factor, plays a crucial role during osteogenic differentiation by acting as a direct repressor of Runx2
Pages S28-S29
Su Jin Park, Jong In Yook, Ji Hyun Byun, Yumie Rhee, Hyun-Mo Ryoo, Eun Jig Lee and Sung-Kil Lim
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32) Effects of PDE7 and PDE8 silencing on gene expression and differentiation in osteoblasts
Page S29
Minna Pekkinen, Mikael Ahlstrom, Ulrike Riehle, Minna M. Huttunen and Christel Lamberg-Allardt
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33) Subchondral bone osteoblasts can induce chondrocyte mineralization during osteoarthritis and this process is relevant to cartilage degradation
Pages S29-S30
Indira Prasadam, Wei Shi, Ross Crawford and Yin Xiao
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34) Alcohol consumption affects osteoblast activities on biomaterials: An in-vitro study
Page S30
Lia Rimondini, Milena Fini, Paola Torricelli, Gianluca Giavaresi, Roberto Chiesa, Enrico Sandrini and Roberto Giardino
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35) Activation of the cAMP/PKA pathway in human mesenchymal stem cells in vitro results in robust bone formation in vivo
Page S30
R. Siddappa, J. Doorn, A. Leusink, C. van Blitterswijk and J. de Boer
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36) Proteasome inhibition protects osteoblasts from glucocorticoid-induced damage, and enhances glucocorticoid-induced toxicity against osteoclasts
Pages S30-S31
Kent Soe, Thomas L. Andersen, Torben Plesner and Jean-Marie Delaisse
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37) Cannabinoid receptor 2 selective agonists stimulate osteoclast formation in vitro but act as anabolic agents in vivo by stimulating bone formation
Page S31
Antonia Sophocleous, Euphemie Landao, Rob vant Hof, Aymen I. Idris and Stuart H. Ralston
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38) Origin of matrix vesicles in mineralization competent osteoblast-like saos-2 cells
Pages S31-S32
Cyril Thouverey, Marcin Balcerzak, Agnieszka Strzelecka-Kiliszek, Slawomir Pikula and Rene Buchet
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39) Polychrome tetracycline bone labelling — new possibilities using spectral image analysis
Page S32
Thomas Tischer, Stephan Vogt, Cornelia Haczek, Horst Zitzelsberger, Stefan Milz and Christoph Pautke
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40) Adipose tissue derived mesenchymal stem cells: differentiation into osteoblastic phenotype and interaction with nanostructured titanium alloys
Pages S32-S33
Isabella Tognarini, Sabina Sorace, Roberto Zonefrati, Gianna Galli, Giorgia D. Zappoli Thyrion, Annamaria Carossino, Alessandro Facchini, Fausto Sbaiz, Annalisa Tanini and Maria Luisa Brandi
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41) Differentially expressed genes in osteoblasts from a pair of osteoporotic and control patients
Page S33
Zoran Trost, Rihard Trebse, Janez Prezelj and Janja Marc
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42) NMDA glutamate receptors expressed in osteoblast precursor cell and osteoblast are involved in the process of mechanotransduction
Pages S33-S34
QiangCheng Zeng, XiZhen Zhang, FuYin Xiong, Yong Guo, ShiYing Zheng, LiYuan Tian, HongLing Liu, JianXin Xing and JiXian Deng
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43) Dkk1 is a possible direct target of Osx
Page S34
Chi Zhang and Benoit de Crombrugghe
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44) Beta-2 adrenoreceptor ligands regulate osteoclast differentiation in vitro by direct and indirect mechanisms
Pages S34-S35
Sarah Aitken, Euphemie Landao-Bassonga, Stuart H. Ralston and Aymen I. Idris
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45) In vitro bone resorption during spaceflight
Page S35
Claudia Camerino, Adriana Di Benedetto, Graziana Colaianni, Roberto Tamma, Giovanni Greco, Maurizio Strippoli, Rosaria Vergari, Antonella Grano, Lucia Mancini and Alberta Zallone
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46) Id1 negatively regulates osteoclast differentiation and maintains hematopoietic stem cell niche homeostasis
Pages S35-S36
April S. Chan, Kristian K. Jensen, Hannah K. Lederman, Rosandra N. Kaplan, Stefano Rivella and David C. Lyden
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47) Fluorescently labeled risedronate and related analogs: Design and evaluation as imaging probes
Page S36
Fraser P. Coxon, Joy L. Bala, Boris A. Kashemirov, Mark W. Lundy, Xiaolan Chen, Zhidao Xia, James E. Dunford, Graham G. Russell, Anke J. Roelofs, Michael J. Rogers, Charles E. McKenna and Frank H. Ebetino
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48) IL-6 inhibits RANKL-induced osteoclastogenesis by diverting cells into the macrophage lineage: Key role of serine727 phosphorylation of STAT3
Page S36
Laurence Duplomb, Marc Baud'Huin, Celine Charrier, Valerie Trichet, Frederic Blanchard and Dominique Heymann
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49) A mirror image pair of bisphosphonate analogs further demonstrates the mode of binding of the bisphosphonates in farnesyl pyrophosphate synthase
Pages S36-S37
Frank H. Ebetino, James E. Dunford, Mark W. Lundy, Michele Pozzi, Zhidao Xia, Roy Dobson, Mike Quijano, Roze Christian, Boris A. Kashemirov, Charles E. McKenna, Graham G. Russell and Bobby L. Barnett
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50) Transcriptional activation of V-ATPase subunit d2 is regulated by NFATc1 in RANKL-induced osteoclastogenesis
Page S37
Haotian Feng, Taksum Cheng, Nathan J. Pavlos, James H. Steer, ChengLoon Leong, Jianzhong Liu, David A. Joyce, Jasreen Kular, Xu Feng, Minghao Zheng and Jiake Xu
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51) Sex steroids hormone mediate osteoprotecitve effects by controlling osteoclast life cycle
Pages S37-S38
Yuuki Imai, Takashi Nakamura, Takahiro Matsumoto, Shingo Sato, Shu Takeda, Katsuhide Igarashi, Yoko Yamamoto, Jun Kanno, Hiroshi Takayanagi, Kunio Takaoka, T.J. Martin, Pierre Chambon and Shigeaki Kato
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52) Effects of hypoxia on osteoclast formation and function: A balance between enhanced resorptive activity and increased apoptosis
Page S38
Helen J. Knowles and Nicholas A. Athanasou
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53) Zoledronic Acid-Induced IPP/ApppI Formation In Vivo and In Vitro
Pages S38-S39
Johanna Kuokkanen, J.C. Crockett, M.J. Rogers, H. Monkkonen, S. Auriola and J. Monkkonen
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54) TRPV4-mediated calcium influx regulates terminal differentiation of osteoclasts
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Ritsuko Masuyama, Thomas Voets, Yuji Karashima, Sofie Torrekens, Karen Moermans, An Vanden Bosch, Roger Bouillon, Bernd Nilius and Geert Carmeliet
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55) The matrix PROLINE/Arginine-Rich End Leucin-Rich Repeat Protein (PRELP) impairs osteoclastogenesis by inhibiting NF-kappaB activity
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Anna Rufo, Marina Alamanou, Nadia Rucci, Mattia Capulli, Dick Heinegard and Anna Teti
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56) Regulation of osteoclastogenesis and osteoimmunology
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Hiroshi Takayanagi
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57) In Vitro osteoclastogenesis during spaceflight
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Roberto Tamma, Graziana Colaianni, Adriana Di Benedetto, Claudia Camerino, Giovanni Greco, Maurizio Strippoli, Rosaria Vergari, Antonella Grano, Lucia Mancini and Alberta Zallone
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58) Stainless steel screws coated with bisphosphonates gave stronger fixation and more surrounding bone. histomorphometry in rats
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Karin Wermelin, Felicia Suska, Pentti Tengvall, Peter Thomsen and Per Aspenberg
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59) Extremely high local doses of alendronate still have positive effects in bone grafts
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Fredrik Agholme and Per Aspenberg
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60) A physical mechanism for coupling bone resorption and formation in adult human bone
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Thomas L. Andersen, Teis E. Sondergaard, Katarzyna E. Skorzynska, Torben Plesner, Trine L. Plesner, Ellen Hauge and Jean-Marie Delaisse
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61) Intermittent 1,25-D3 and calcitonin combo restores bone in OVX Rats
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Cedo M. Bagi, Edwin Berryman, Maria Moalli and Catharine J. Andresen
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62) Is Vit D is an intrinsic factor resposable for diseases
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Akhter Mohammad Baig
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63) Endorphins regulate bone homeostasis by actions through dynorphin
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Paul A. Baldock, Iris Wong, Michelle McDonald, Ron F. Enriquez, Christoph Scwarzer, David G. Little, Amanda Sainsbury, Herbert Herzog and John A. Eisman
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64) New approach to bone strength measurement
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Antonio Bazarra-Fernandez
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65) New paradigm: hydroxyapatite versus calcium carbonate
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Antonio Bazarra-Fernandez
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66) Local treatment of cancellous bone grafts with BMP-7 and zoledronate increases both bone formation and bone density. A bone chamber study in rats
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Ola Belfrage, Uldis Kesteris and Magnus Tagil
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67) The IATROS study — ibandronate for treatment of renal osteodystrophy
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Raoul Bergner, Martin Hoffmann and Michael Uppenkamp
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68) Calcium release from bone in postmenopausal women: Effects of low level cadmium exposure
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Maryka Bhattacharyya, Andrea Ebert-McNeill, Elizabeth Cerny, Manisha Chandar, Sara Clark and James Miller
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69) Mice treated with a myostatin/GDF-8 decoy receptor, ActRIIB-Fc, exhibit a tremendous increase in bone mass
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Peter Bialek, Jascha Parkington, Loraine Warner, Michael St. Andre, Li Jian, Donna Gavin, Catherine Wallace, Jimin Zhang, Grace Yan, Adam Root, Howard Seeherman and Paul Yaworsky
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70) Parity and risk of non-vertebral fractures in the tromso study
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Ashild Bjornerem
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71) Possible role of oxytocin in energy homeostasis
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Claudia Camerino, Maurizio Strippoli and Rosaria Vergari
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72) Effect of a selective p38alpha inhibitor on trabecular bone loss induced by estrogen deficiency
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Joseph Caverzasio and Patrick Ammann
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73) Fat distribution in a vitamin D deficient population: Correlation between PTH levels and W/H ratio
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Pierluigi De Remigis, Paola Ranieri, Alessandra De Remigis, Stefano Porfiri and Luigi Vianale
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74) Fat children, thin bones
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Paul J. Dimitri, Paul Arundel, Jerry K.W. Wales and Nick J. Bishop
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75) Towards understanding of trabecular bone failure by deformation localisation
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John W.C. Dunlop, Richard Weinkamer, Yves J. Brechet and Peter Fratzl
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76) The aging associated gene SIRT-1 controls bone mass in vivo through osteoblast and osteoclast regulation
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James R. Edwards, Kayvan Zainabadi, Florent Elefteriou, Frederick Alt, Leonard Guarente and Gregory R. Mundy
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77) Calcium density of bone correlates with trabecular bone architecture
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N.L. Fazzalari, B. Ma, P. Sutton-Smith, J.S. Kuliwaba, R.J. Phipps, I.H. Parkinson and A. Badiei
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78) Gender-specific control of peak bone mass by the Wnt pathway: Androgen signaling protects against lef1 haploinsufficiency-induced bone loss
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Yankel Gabet, Tommy Noh, Jon Cogan, Archana Tank, Tomoyo Sasaki, Braiden Criswell, Alexis Dixon, Joseph Tam, Thomas Kohler, Eran Regev, Lisa Kockeritz, James Woodgett, Ralph Muller, Yang Chai, Elisheva Smith, Itai Bab and Baruch Frenkel
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79) Surprising lifetime effects of deletion of the mouse calcitonin gene
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Robert F. Gagel, Ana O. Hoff, Su-chen E. Huang and Gilbert J. Cote
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80) Biphasic effects of PTH on cell viability and anabolic gene expression in human osteoblastic cells
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J.A. Gallagher, J.P. Dillon, E.L. Pacheco-Pantoja, P.M. Wilson, K.A. Buckley and W.D. Fraser
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81) Osteogenic differentiation of marrow cells in response to hedgehog stimulation in vivo
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Kris Gellynck, Dan Deng, Robert Brown, Wei Liu and Paul Buxton
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82) Hypoxia exerts differential effects on the chondrogenic and osteogenic differentiation of human adipose-derived mesenchymal stem cells
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Jerome Guicheux, Christophe Merceron, Martial Masson, Lydie Guigand, Jerome Amiaud, Yann Cherel, Maithe Gatius, Pierre Weiss and Claire Vinatier
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83) Ibandronate affects callus formation and mechanical properties during fracture repair in ovariectomized Sprague–Dawley rats after 4 weeks of treatment
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Bjorn Habermann, Gavin Olender, Christian Eberhardt, Peter Augat and Andreas Kurth
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84) Strong and significant genetic effects on osteonal remodeling-associated cortical bone microstructure in pedigreed baboons
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Lorena M. Havill, Jennifer A.K. Harris, Shayna M. Levine and Michael C. Mahaney
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85) Homocysteine reduces bone quality by stimulation of osteoclasts
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Markus Herrmann, Andrea Tami, Johannes P. Schmidt, Wagner Alexandra, Natalia Umanskaya, Heike Schorr, Ulrich Huebner, Steffen Ross, Britt Wildemann and Wolfgang Herrmann
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86) Potential excessive suppression of bone turnover with long-term oral bisphosphonates therapy in postmenopausal osteoporotic patients (prospective study monitored with biochemical marker of bone turnover)
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Takahiro Iizuka and Mitsuhiro Matsukawa
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87) Effects of TGF-?3 on osteocytes of Ex Vivo human cancellous bone explants
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Katharina Jahn, Martin J. Stoddart, Pamela I. Furlong, Charles W. Archer and Geoff R. Richards
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88) Review of women referred for osteoporosis scanning in the year 2005
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Kavin Jayawardhana
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89) No disease-causing mutations in LRP6 or PTHrP found in 26 patients with juvenile idiopathic osteoporosis
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Dror Koltin, Christine M. Laine, Anne Saarinen, Miki Susic, Kathy Parker, William G. Cole, Etienne Sochett and Outi Makitie
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90) Protein phosphatase PP2A mediates FGF-induced p107 dephosphorylation in chondrocytes
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Victoria Kolupaeva, Emmanuel Laplantine and Claudio Basilico
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91) PTH-induced bone anabolism is blunted in SOST overexpressing mice
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Ina Kramer, Gabriela G. Loots and Michaela Kneissel
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92) The high bone mass phenotype of Sost deficient mice is characterized by progressive increase in bone thickness, mineralization and predicted cortical bone strength in a gene dosage unrelated manner
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Ina Kramer and Michaela Kneissel
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93) Regulation of hypoxia-induced cell death in human tenocytes
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Min Liang, Richard T. Benson, Andrew J. Carr and Philippa A. Hulley
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94) Loss of the vitamin D receptor in the intestine induces severe bone loss to preserve normal calcemia
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Liesbet Lieben, Ritsuko Masuyama, Ingrid Stockmans, Karen Moermans, Roger Bouillon and Geert Carmeliet
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95) Measuremnts of bone mineral density and content in avian species
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Annette Liesegang, Ruth Messikommer and Isabel Fischer
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96) Excess dietary vitamin A reduces osteoclast activity in rats
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Thomas Lind, P. Monica Lind, Annica Jacobsson, Juha Risteli, Goran Andersson and Hakan Melhus
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97) Changes of bone mineral density and bone biomechanics in type 2 diabetic model of female rats
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Yaping Liu, Hong Ji, Haiqin Rong, Liping Zhang, Xinbo Zhao and Zhanjun Qiu
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98) Growth hormone stimulates proliferation and differentiation of M2H4 odontoblastic cell line
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Serena Lopez-Cazaux, Thomas Cordonnier, Marion Julien, Martial Masson, Maithe Gatius, Solmaz Khoshniat, Pierre Weiss, Jerome Guicheux and Brigitte Alliot-Licht
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99) Changes in blood supply and bone regeneration induced by nicotine during distraction osteogenesis
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Li Ma, Li Wu Zheng and Lim Kwong Cheung
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100) Disease and treatment parameters significantly affect skeletal complications and survival in metastatic breast cancer
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Pierre P. Major, Richard J. Cook, Allan Lipton and Evangelos Terpos
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101) Understanding the process of force-induced bone growth and adaptation through a mathematical model
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Solvey Y. Maldonado, Rolf Findeisen and Frank Allgower
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102) The role of Dkk-1 in human osteosarcoma and its regulation
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Helen S. McCarthy, John H.H. Williams and Michael J. Marshall
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103) Erythropoietin: A novel DABA?
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Nancy Morabito, Agostino Gaudio, Enza Maria Galati, Simona Pergolizzi, Maria Fernanda Taviano, Antonino Lasco, Ilaria Macri, Antonino Catalano, Marco Atteritano, Francesco Occhiuto, Elisa Corrente, Giancarlo Crisafulli and Nicola Frisina
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104) Diet-induced Hyperinsulinaemia negatively affects bone in male C57/BL mice
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Janina M. Patsch, Florian Kiefer, Martina Rauner, Daniela Stupphann, Heinrich Resch, Thomas Stulnig and Peter Pietschmann
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105) High dose of Zoledronic acid inhibits both osteoclasts and osteoblasts in an In Vivo mouse model
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Samantha Pozzi, Teru Hideshima, Sonia Vallet, Siddhartha Mukherjee, Shweta Chhetri, Diana Cirstea, Nileshwari Vaghela, Clare Thomas, Dilani Rosa, Eyal Rosen, Hiroshi Ikeda, Yutaka Okawa, Iris Breitkreutz, Tanyel Kiziltepe, Loredana Santo, Jesse Schoonmaker, Ernestina Schipani, Mary L. Bouxsein, Kenneth C. Anderson and Noopur S. Raje
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106) The involvement of IHH-PTHrP feedback loop in the effect of loading and release from Loading on the Growth Plate
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Adi Reich and Efrat Monsonego Ornan
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107) Complex transitions in the Bone Mineralization Density Distribution (BMDD) caused by changes in bone turnover
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Davide Ruffoni, Peter Fratzl, Carolin Lukas, Paul Roschger, Klaus Klaushofer and Richard Weinkamer
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108) Carbon dioxide rich water bathing increase local VEGF, angiopoietin-I, BGP secretions in ischemic lower limbs of DM hemodialysis patients
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Kazuhiro Saito
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109) Purification of matrix Gla protein and osteocalcin from the adriatic sturgeon (Acipencer naccarii), an Ancient bony fish with a cartilaginous endoskeleton
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Dina C. Simes, Carla B. Viegas, Matthew K. Williamson, Paul A. Price and Leonor Cancela
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110) Effects of global knockout or over-expression of fibroblast growth factor-2 in osteoblasts on fracture healing in transgenic mice
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Liping Xiao, Douglas Adams, Liping Wang, Xi Jiang and Marja M. Hurley
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111) Serum proinflammatory cytokines (IL-1?, IL-6 and TNF-?) levels and bone mineral density at femur and vertebrae in type 2 diabetic rat
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Liping Zhang, Haiqin Rong, Hong Ji and Dong Wang
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112) Skeletal characters in type 2 diabetic rat model induced by high fat diet and low dose streptozotocin
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Liping Zhang, Haiqin Rong, Hong Ji, Yaping Liu and Dong Wang
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113) Influence of frequency of mechanical traction on gene expression and angiogenesis in rabbit mandibular lengthening
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Li Wu Zheng, Li Ma and Lim Kwong Cheung
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114) Screening for Osteoporosis — fracture patients care! 3-year follow-up of 215 fracture patients from a prospective and consecutive osteoporosis screening program
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Jorgen Astrand, Karl-Goran Thorngren, Magnus Tagil and Kristina Akesson
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115) Treatment of painful bone marrow edema syndrome with intravenous ibandronate
Pages S67-S68
Ch. Bartl, R. Bartl, G. Salzmann and A. Imhoff
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116) Therapy of paediatric bone conditions
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Nick J. Bishop
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117) Effects of PTH on tibial bone of ovariectomized rats assessed by In Vivo Micro-CT
Pages S68-S69
Julienne E.M. Brouwers, Bert van Rietbergen, Rik Huiskes and Keita Ito
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118) Bone mineral density and biochemical marker response rates in postmenopausal women after treatment with zoledronic acid
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Pierre D. Delmas, Ian Reid, Rene Rizzoli, Silvano Adami, Philip Sambrook, Erik F. Eriksen, Peter Mesenbrink and Richard Eastell
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119) Anabolic activity of black bear PTH
Pages S69-S70
Seth W. Donahue, Meghan E. McGee and Kirsten Simoni
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120) Comparison of bone architecture via micro-ct after long-term treatment with risedronate and alendronate: A cross-sectional study in women with postmenopausal osteoporosis
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T.E. Dufresne, P.A. Chmielewski, J.H. Nurre, B. Borah, X. Zhou, R.J. Phipps, G. Woodson and P.D. Miller
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121) The interaction of sidechain nitrogen with active site threonine is not essential for inhibition of farnesyl pyrophosphate synthase by nitrogen containing bisphosphonates
Pages S70-S71
James E. Dunford, Ewa Pilka, Aaron A. Kwaasi, Artem Evdokimov, Bobby L. Barnett, Udo Oppermann, Frank H. Ebetino, R. Graham G. Russell and Kathryn L. Kavanagh
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122) Structure activity relationships of nitrogen containing bisphosphonates which induce conformational changes in farnesyl pyrophosphate synthase
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James E. Dunford, Aaron A. Kwaasi, Kathryn L. Kavanagh, Michael J. Rogers, Udo Oppermann, Bobby B. Barnett, Frank H. Ebetino, R. Graham and G. Russell
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123) Short-time zoledronic acid pretreatment stimulates osteogenic differentiation of human mesenchymal stem cells
Pages S71-S72
Regina Ebert, Ralf Krug, Jutta Meissner-Weigl, Sabine Zeck, Doris Schneider and Franz Jakob
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124) Artificial extracellular matrices for bone tissue engineering
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Martin Ehrbar, Matthias P. Lutolf, Simone C. Rizzi, Jeffrey A. Hubbell and Franz E. Weber
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125) New mechanisms for old targets: Novel approaches to steroid receptors in drug discovery
Pages S72-S73
Leonard P. Freedman
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126) Comparing the serum levels of 25(oh)d3 after 12 months of treatment with a Fixed combination of weekly alendronate plus cholecalciferol 2800 UI with these of weekly alendronate plus daily calcium 500 mg and vitamin D 400 UI
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A.E. Georgiadis, E. Pini, R. Alkiviadis, D. Karabatsas and I. Mandrekas
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127) Are there any effects of angiotensin II receptor blockers on postmeneuposal osteoporosis?
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Erim Gulcan, Aynur Gulcan, Serdar Toker and Emine Cosar
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128) Enhanced expression of BMP2/Smad pathway and SP7 by statins during fracture repair
Pages S73-S74
Gloria E. Gutierrez, Jianghong Zhang, Satyawan Jadhav, Munoz A. Steve and Gregory R. Mundy
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129) A randomized, double-blind, placebo-controlled study of a cathepsin-K inhibitor in the treatment of postmenopausal women with Low BMD: 18 month results
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Avery Ince, Michael McClung, Henry Bone, Nadia Verbruggen, Andrea Rybak-Feiglin, Carolyn daSilva and Arthur Santora
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130) Relationship between osteoporosis and living/working environment
Pages S74-S75
Z. Karaiskoy, A. Georgoyntzos, M. Pantazopoylos, M. Dimosthenis, P. Xristogiorgos, P. Gkikas, K. Stratigos, M. Merakoy and A.E. Georgiadis
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131) Anti-resorptives did not hinder the short term increase of bone turnover by teriparatide in patients with osteoporosis
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Kyoung Min Kim, Yumie Rhee, Dong Yeob Shin, Cheol Ryong Ku, Han Seok Choi, Eun Jig Lee and Sung-Kil Lim
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132) Effect of red ginseng on osteoporotic lumbar traecular bone of rats
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Changyong Ko, Hanshung Kim, Songhee Park, Juseop Kang and Sangjun Lee
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133) The toughness of bone and the influence of bisphosphonates on the resistance to fracture
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Kurt J. Koester, Joel W. Ager and Robert O. Ritchie
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134) Early and sustained non-vertebral fracture efficacy with risedronate
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Robert Lindsay, Christian Roux, Jonathan D. Adachi, Xiaojie Zhou, Andreas Grauer and Nelson B. Watts
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135) Effect of previous bisphosphonate use on response to zoledronic acid: Results from the HORIZON-PFT study
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Kurt Lippuner, Richard Eastell, Ian Reid, Claude-Laurent Benhamou, Chris Recknor, Sophia Ish-Shalom, Gerolamo Bianchi, Dennis Black, Peter Mesenbrink, Erik Fink Eriksen and Pierre D. Delmas
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136) Biology of fracture healing and effect of osteoporosis therapies
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David G. Little
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137) Similarities and differences of responses to intravenous (I.V.) bisphosphonate treatment (pamidronate) in postmenopausal and steroid-induced osteoporosis
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Polyzois Makras, Neveen A.T. Hamdy and Socrates E. Papapoulos
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138) PTH treatment increases fracture callus size and strength more effectively in closed than open fractures
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Michelle M. McDonald, Magnus Tagil, Alyson Morse, Craig B. Godfrey, Negin Amanat and David G. Little
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139) Differing effects of pre and post-fracture bisphosphonate treatment on bone repair in estrogen-deficient rats
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Michelle M. McDonald, Kathy Mikulec, Lauren Peacock, Paul A. Baldock and David G. Little
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140) Normal endochondral fracture union follows continuous bisphosphonate pre-treatment in a rat closed fracture model
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Michelle M. McDonald, Alyson Morse, Kathy Mikulec, Haoi-Lan Mai, Craig Munns and David G. Little
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141) Bilateral avascular necrosis of the femoral head and teriparatide: Consequence or coincidence
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Malachi J. McKenna
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142) The small molecule N-Methyl pyrrolidone tunes the natriuretic peptide hormone system into a pro osteogenic state
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Grahame McKenzie, Bryn Hardwick, Blanca SanMiguel, Bik Chopra, Giovanna Creasey, Dirk Gewert and Franz E. Weber
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143) BMD and wrist fracture: Sinergy between nutrition complex and clodronate
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M. Muratore, E. Quarta, L. Quarta, F. Calcagnile, A. Casto and G. Rollo
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144) Body mass and wrist fracture: Sinergy between nutrition complex and clodronate
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M. Muratore, G. Rollo, A. Casto, E. Quarta, L. Quarta and F. Calcagnile
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145) Interventions for alveolar bone regeneration in a gingivoperiosteoplasty model
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Phuong D. Nguyen, Clarence D. Lin, Alessandro C. Allori, Tom Reisler, Pierre B. Saadeh, Jamie P. Levine and Stephen M. Warren
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146) Inhibition of Osteoblast function by bisphosphonates
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Isabel R. Orriss, Michelle L. Key, Kay W. Colston and Timothy R. Arnett
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147) Treatment with RAP-011 (A soluble activin receptor type IIA) increases bone mineral density in mice with prior bisphosphonate exposure
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R. Scott Pearsall, Michelle Mangini, Milton Cornwall-Brady, Travis Monnell, Tod Marvell, Brendan Haigis, Ravindra Kumar, Kathryn W. Underwood and Jasbir Seehra
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148) Effect of intravenous pamidronate for treatment of severe osteoporosis in postmenopausal women
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Vladyslav V. Povoroznyuk, Marina A. Bystrytska, Tatyana V. Orlyk, Natalija I. Dzerovych, Vladymyr M. Vayda and Natalija A. German
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149) Fosamax in treatment of postmenopausal osteoporosis and its complications
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Vladyslav V. Povoroznyuk, Pavel I. Nikonenko and Natalija V. Grygoryeva
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150) Effect of alendronate in postmenopausal women with systemic osteoporosis treatment
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Vladyslav V. Povoroznyuk, Tatyana V. Orlyk and Nataliya I. Dzerovych
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151) Persistence is important in effectiveness of various anti-resorptive agents in Korean postmenopausal women with osteoporosis
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Yumie Rhee, Kyoung Min Kim, Dong Yeob Shin, Cheol Ryong Ku, Han Seok Choi, Eun Jig Lee and Sung-Kil Lim
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152) Nitrogen-containing bisphosphonates induce IPP/DMAPP accumulation selectively in peripheral blood monocytes due to efficient drug uptake
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Anke J. Roelofs, Marjo Jauhiainen, Hannu Monkkonen, Michael J. Rogers, Jukka Monkkonen and Keith Thompson
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153) Use of a fluorescent analogue of risedronate to study localisation and cellular uptake of bisphosphonates in vivo
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Anke J. Roelofs, Fraser P. Coxon, Frank H. Ebetino, Joy F. Bala, Boris A. Kashemirov, Charles E. McKenna and Michael J. Rogers
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154) Effects of teriparatide on quality of life in postmenopausal women with osteoporosis
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Jan Rosa, Petr Kasalicky and Ivana Mala
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155) Oral ibandronate reduces non-vertebral fracture risk in postmenopausal osteoporosis: Results from a sub-analysis of a pivotal study
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Jacob A. Stakkestad, Ronald Emkey, Colin Neate and Charles H. Chesnut
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156) Structure activity relationships of phosphonocarboxylate inhibitors of rab geranylgeranyl transferase
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Charlotte A. Stewart, Rudi Baron, Mong S. Marma, Katarzyna M. Blazewska, Boris A. Kashemirov, Frank H. Ebetino, Charles E. McKenna, Michael J. Rogers and Fraser P. Coxon
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157) Differential inhibition of rab geranylgeranyl transferase by stereoisomers of phosphonocarboxylates
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Charlotte A. Stewart, Rudi Baron, Katarzyna M. Blazewska, Boris A. Kashemirov, Frank H. Ebetino, Javier Rojas Navea, Michael J. Rogers, Charles E. McKenna and Fraser P. Coxon
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158) Enhanced Pin fixation for un-coated standard pins by a single bisphosphonate infusion in hemicallotasis osteotomy. A double-blinded placebo controlled randomized study
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Magnus Tagil, Annette W.-Dahl, Anna Kajsa Harding, David Little and Soren Toksvig Larsen
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159) Repairing nonunion in rat femur with rhBMP-2 and biodegradable carrier
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Susumu Taguchi, Masatoshi Hoshino, Takashi Namikawa, Yoshio Tokuhara and Kunio Takaoka
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160) Characterisation of the inhibition of rab prenylation by phosphonocarboxylates
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Richard Tavare, Rudi Baron, Adam Taylor, Miguel C. Seabra, Katarzyna M. Blazewska, Charles E. McKenna, Boris A. Kashemirov, Frank H. Ebetino, Michael J. Rogers and Fraser P. Coxon
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161) Nebivolol may be beneficial via nitric oxide on osteoporosis treatment
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Serdar Toker, Aysun Toker, Erim Gulcan and Aynur Gulcan
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162) Calcium phosphate biomaterials for a local-delivery of bisphosphonate: Influence of chemical association on the in vitro activity
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Elise Verron, Helene Roussiere, Bruno Bujoli, Pascal Janvier, Jean Michel Bouler and Jerome Guicheux
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163) Vertebral fracture efficacy with risedronate is apparent early and is sustained
Pages S89-S90
Nelson B. Watts, Christian Roux, Xiaojie Zhou and Andreas Grauer
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164) Is the ApaI VDR polymorphism a good indicator of effectivenes of alendronate therapy?
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Anna Wawrzyniak, Wanda Horst Sikorska, Michalina Marcinkowska, Robert Kalak and Ryszard Slomski
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165) Evaluation of the relative mineral-binding affinities of clinically-relevant bisphosphonates by using hydroxyapatite-column chromatography and adsorption isotherms combined with mass spectrometric analysis
Pages S90-S91
Zhidao Xia, Xuchen Duan, Rachel M. Locklin, Mike Quijano, Roy L.M. Dobson, James T. Triffitt, Frank H. Ebetino and Graham R.G. Russell
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166) Pioglitazone affects bone resorption but not bone formation
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Maria P. Yavropoulou, Helen P. Vafiadou, Olympia E. Anastasiou, Vasiliki Tsavdaridou, Georgia H. Kokaraki and John G. Yovos
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167) Tumor-associated osteoclast activity and aggressiveness of osteosarcoma
Pages S91-S92
Sofia Avnet, Alessandra Longhi, Manuela Salerno, Jussi Halleen, Francesca Perut, Donatella Granchi, Armando Giunti and Nicola Baldini
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168) Bisphosphonate-associated osteonecrosis of the jaw: A pathophysiologic approach
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R. Bartl and G. Mast
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169) Acute suppression of bone turnover predicts bone turnover changes at 3 months in bone metastatic patients treated with zoledronate
Pages S92-S93
Francesco Bertoldo, Serena Pancheri, Sonia Zenari, Luca Dalle Carbonare and Vincenzo Lo Cascio
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170) Oncostatin M induces bone loss and sensitizes rat osteosarcoma to the anti-tumor effect of midostaurin in vivo
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Benedicte Brounais, Celine Chipoy, Kanji Mori, Severine Battaglia, Carl Richards, Dominique Heymann, Francoise Redini and Frederic Blanchard
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171) CYR61 down-modulation induced by zoledronic acid impairs cell motility and sensitizes prostate cancer cells to docetaxel: A new anti-cancer strategy
Page S93
M. Caraglia, M. Marra, G. Meo, S.R. Addeo, B. Vincenzi, A. Baldi, S. Zappavigna, M. Rosolowski, M. Loeffler, A. Budillon, G. Tonini and D. Santini
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172) Differential effects of host-derived mmps on development of multiple myeloma in vivo
Page S94
Claire M. Edwards, Conor C. Lynch, Jessica A. Fowler, Kathy Carter, Seint T. Lwin, Lynn M. Matrisian and Gregory R. Mundy
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173) TNF-Related Apoptosis Inducing Ligand (TRAIL) inhibits primary bone tumor growth and augments survival in a human model ewing sarcoma
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Loic Geffroy, Damien Chauviere, Francois Lamoureux, Gaelle Picarda, Olivier Delattre, Susan Burchill, Pascal Delepine, Francois Gouin, Dominique Heymann and Francoise Redini
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174) Macrophage Inflammatory Protein (MIP)-3?/CCL20 and its receptor CCR6 are overexpressed in the bone microenvironment and involved in osteoclast formation in multiple myeloma patients: Potential relationship with the presence of osteolytic lesions
Page S95
Nicola Giuliani, Gina Lisignoli, Sara Tagliaferri, Francesca Morandi and Vittorio Rizzoli
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175) Renal function changes and resource use in patients with metastatic bone disease treated with IV zoledronic acid or oral ibandronic acid: Interim results
Pages S95-S96
Stephen J. Houston, Robert J. Grieve, Fran Percival, Nicola J. Fisher and Liz Hamilton
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176) Effects of osteoblast-like cells on bone-related and invasive gene expressions in breast cancer cells
Page S96
Hichame IdBoufker, Laurence Lagneaux, Tatiana Tondreau, Hugues Duvillier, Jean-Jacques Body and Fabrice Journe
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177) The Src inhibitor dasatinib inhibits breast cancer cell growth in vitro and exerts synergistic effects with bisphosphonates
Pages S96-S97
Fabrice Journe, Naima Kheddoumi, Carole Chaboteaux, Christos Sotiriou, Martine Piccart and Jean-Jacques Body
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178) Farnesoid X receptor in primary breast carcinoma: A new marker to predict bone metastasis?
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Fabrice Journe, Virginie Durbecq, Carole Chaboteaux, Ghislane Rouas, Hichame IdBoufker, Guy Laurent, Denis Larsimont and Jean-Jacques Body
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179) Intravenous and Oral ibandronate are equally effective in metastatic bone pain reduction regardless of previous bisphosphonate treatment
Pages S97-S98
Henning Kuhnle, Jorg Seraphin, Harald Meden and Johannes Ziegler
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180) The compare study — an assessment of renal toxicity of ibandronate and zoledronic acid in multiple myeloma patients
Page S98
Wolfgang Knauf, Bernd Gaede, Raoul Bergner and Johannes Ziegler
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181) Bone pain reduction by intense bisphosphonate therapy in patients with newly diagnosed bone metastases
Pages S98-S99
A.A. Kurth, C. Eberhardt, U. Stumpf and A. Muller
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182) The effect of adjuvant chemotherapy with a taxane and a bisphosphonate on bone mass and bone strength in an animal model
Page S99
A.A. Kurth, M. Shea, B. Janz, P. Augat and A. Muller
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183) Inhibition of osteopontin expression in glioma cancer cells reduces tumor growth and delays mortality after intracranial grafting to nude mice
Pages S99-S100
Virginie Lamour, Marie Le Mercier, Florence Lefranc, Robert Kiss, Martin Hagedorn, Andreas Bikfalvi, Vincent Castronovo and Akeila Bellahcene
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184) Dentin sialophosphoprotein is expressed in human glioblastoma
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Virginie Lamour, Natalia Martinez-Castellanos, Vincent Castronovo and Akeila Bellahcene
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185) Proteoglycans are Potential Regulators of Osteoprotegerin (OPG) antitumoral and anti-bone resorption activities in osteosarcoma
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Francois Lamoureux, Gaelle Picarda, Valerie Trichet, Bruno Pitard, Dominique Heymann and Francoise Redini
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186) Therapeutic efficacy of soluble receptor activator of NF-kB (RANK) delivered by non viral gene transfer in a mouse model of osteolytic osteosarcoma
Pages S100-S101
Francois Lamoureux, Gaelle Picarda, Julie Rousseau, Clothilde Gourden, Severine Battaglia, Celine Charrier, Bruno Pitard, Dominique Heymann and Francoise Redini
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187) Adjuvant therapy with ibandronate in patients with locally advanced prostate cancer
Page S101
T. Lindenmeir, M. Ulrich, O. Rau, F. Reiher and E.P. Allhoff
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188) Synergistic inhibitory activity of zoledronic acid and paclitaxel on bone metastasis in nude mice
Pages S101-S102
Shun Lu, Jie Zhang, Zhen Zhou, Mei-lin Liao, Wei-zhong He, Xiao-yan Zhou, Zi-ming Li, Jia-ging Xiang, Jie-jun Wang and Hai-quan Chen
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189) Targeting of apoptotic pathways in cancer cells by zoledronic acid
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Laura Mitrofan-Oprea, Marjo Jauhiainen, Jukka Pelkonen and Jukka Monkkonen
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190) Zoledronic acid-induced IPP accumulation in cancer cells strongly correlates with gammadelta T-Cell mediated cancer cell death
Pages S102-S103
Hannu Monkkonen, Ismahene Benzaid, Verena Stresing, Jonathan Green, Jukka Monkkonen, Jean L. Touraine and Philippe Clezardin
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191) The premetastatic niche
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Gregory R. Mundy
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192) Determination of ibandronate in renal tissue
Page S103
B. Nauth, H. Faust, S. Zelger and R. Bergner
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193) Comparison of nephrotoxicity of zoledronate and ibandronate in rats with mild renal insufficiency — laboratory findings
Pages S103-S104
B. Nauth, B. Kranzlin, N. Gretz and R. Bergner
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194) Comparison of nephrotoxicity of zoledronate and ibandronate in rats with mild renal insufficiency — histological findings
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B. Nauth, B. Kranzlin, N. Gretz and R. Bergner
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195) Farnesyl diphosphate synthase is involved in the resistance to zoledronic acid of osteosarcoma cells
Pages S104-S105
Benjamin Ory, Gatien Moriceau, Valerie Trichet, Frederic Blanchard, Martine Berreur, Francoise Redini, Mike Rogers and Dominique Heymann
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196) Mandibular osteonecrosis induced by bisphosphonates — clinical case reports
Page S105
Victor P. Palarie
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197) Preclinical renal safety profile of ibandronate
Pages S105-S106
T. Pfister, E. Atzpodien and F. Bauss
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198) Antineoplastic activity of bone-targeted nanoparticles loaded with doxorubicin
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Manuela Salerno, Sofia Avnet, Caterina Fotia, Elisabetta Cenni, Donatella Granchi, Francesco Castelli, Dorotea Micieli, Rosario Pignatello, Armando Giunti and Nicola Baldini
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199) In vivo effects of zoledronic acid on peripheral ?/? t lymphocytes in early breast cancer patients
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Daniele Santini, Federico Martini, Maria Elisabetta Fratto, Sara Galluzzo, Bruno Vincenzi, Chiara Agrati, Federica Turchi, Paola Piacentini, Laura Rocci, Giuseppe Tonini and Fabrizio Poccia
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200) Prospective observational study (ZORES Study) on analysis of genetic mutations and enzymatic activity of Farnesyl Pyrophosphate Synthetase (FPPS) as predictive factor of resistance to amino-bisphosphonates (N-BP) in patients with bone metastases from solid tumors
Page S107
Daniele Santini, Sara Galluzzo, Bruno Vincenzi, Silvia Angeletti, Michele Caraglia, Giordano Dicuonzo and Giuseppe Tonini
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201) Renal safety profile of ibandronate 6mg infused over 15 or 60 min in breast cancer patients with bone metastases
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F. Schutz, R. von Moos, C.B. Caspar, R. Angst, R. Inauen, R. Greil, J. Ziegler and M. Pecherstorfer
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202) Regular dosing of zoledronic acid maintains continuous suppression of osteolysis in patients with malignant bone disease
Pages S107-S108
Horst Schran, Christina Ravera, Andrej Skerjanec and Manon Boisclair
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203) Sagopilone (ZK-EPO) inhibits bone destruction and tumor burden more efficiently than paclitaxel in a mouse model of established breast cancer bone metastasis
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Anne Strube, Elizaveta Stepina, Ulrich Klar, Peter Hauff, Jens Hoffmann and Sanna-Maria Kakonen
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204) Zoledronic acid induces caspase dependent apoptosis in renal cancer cell lines
Pages S108-S109
Anders Ullen, Lena Lennartsson, Karl-Mikael Kalkner, Per Sandstrom, Bo Lennernas, Stig Linder and Sten Nilsson
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205) Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of rb, mimics the human disease
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Carl R. Walkley, Rameez Qudsi, Vijay G. Sankaran, Monica Gostissa, Stanford I. Roth, Stephen J. Rodda, Erin Snay, Patricia Dunning, Frederic H. Fahey, Frederick W. Alt, Andrew P. McMahon and Stuart H. Orkin
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206) Stem cells, small RNAs, and self-renewal
Pages S109-S110
Haifan Lin
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207) Molecular interactions of disseminated tumor cells with the microenvironment of the bone marrow
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Tatjana Kaiser and Gerd Klein
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208) IBMS Davos Workshops: Author Index
Pages S111-S114
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209) IBMS Davos Workshops: Keywords Index
Pages S115-S116
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