[Ortho] ScienceDirect Alert: Bone, Vol. 48, Iss. 1, 2011

Ср Дек 22 20:49:51 YEKT 2010

New Volume/Issue is now available on ScienceDirect!

*  Bone
   Volume 48, Issue 1, Pages S1-S56, 1-166 (1 January 2011)
   Skeletal Complications of Cancer - including Abstracts from the 10th International Conference on Cancer-Induced Bone Disease, 10th International Conference on Cancer-Induced Bone Disease
   Shefﬁeld, UK
   22-25 September 2010
   Edited by Gregory R. Mundy, Matthew R. Smith and T. John Martin
   http://www.sciencedirect.com/science/issue/4987-2011-999519998-2820740

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TABLE OF CONTENTS

1) Editorial Board
Pages i-ii
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2) IBMS Elected Board of Directors 2010–2011
Page 1
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3) IBMS 2011 Corporate Partners
Page 2
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4) IBMS Membership Application
Page 3
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   Special Issue Forward
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5) Foreword: Skeletal Complications of Cancer
Page 5
Matthew R. Smith, T. John Martin
http://www.sciencedirect.com/science?_ob=GatewayURL&_method=citationSearch&_urlVersion=4&_origin=SDVIALERTASCII&_version=1&_uoikey=B6T4Y-517BB7J-7&md5=c0fb84cb5dcfd3306ce4fa2f9731e173

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   Review Articles
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6) Advances in the biology of bone metastasis: How the skeleton affects tumor behavior
Review Article, 
Pages 6-15
Julie A. Sterling, James R. Edwards, T. John Martin, Gregory R. Mundy
http://www.sciencedirect.com/science?_ob=GatewayURL&_method=citationSearch&_urlVersion=4&_origin=SDVIALERTASCII&_version=1&_uoikey=B6T4Y-50JHBXM-2&md5=e29b1f2ed11edd6c1caee42ecf901286

7) Dysregulation of developmental pathways in bone metastasis
Review Article, 
Pages 16-22
Nilay Sethi, Yibin Kang
http://www.sciencedirect.com/science?_ob=GatewayURL&_method=citationSearch&_urlVersion=4&_origin=SDVIALERTASCII&_version=1&_uoikey=B6T4Y-50HDT8M-3&md5=a329b17a48bf3cd67ce6892f5630e8aa

8) TGF-β in cancer and bone: Implications for treatment of bone metastases
Review Article, 
Pages 23-29
Patricia Juárez, Theresa A. Guise
http://www.sciencedirect.com/science?_ob=GatewayURL&_method=citationSearch&_urlVersion=4&_origin=SDVIALERTASCII&_version=1&_uoikey=B6T4Y-50R6KD7-2&md5=b15acfaf7159fd29940a3f8de82f2057

9) Metastatic bone disease: Role of transcription factors and future targets
Review Article, 
Pages 30-36
Jitesh Pratap, Jane B. Lian, Gary S. Stein
http://www.sciencedirect.com/science?_ob=GatewayURL&_method=citationSearch&_urlVersion=4&_origin=SDVIALERTASCII&_version=1&_uoikey=B6T4Y-506RN2S-3&md5=1c1a5dd1619eb77ff5184d5a813f810a

10) Epithelial plasticity, cancer stem cells and bone metastasis formation
Review Article, 
Pages 37-43
Gabri van der Pluijm
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11) Matrix metalloproteinases as master regulators of the vicious cycle of bone metastasis
Review Article, 
Pages 44-53
Conor C. Lynch
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12) Integrins and bone metastasis: Integrating tumor cell and stromal cell interactions
Review Article, 
Pages 54-65
Jochen G. Schneider, Sarah R. Amend, Katherine N. Weilbaecher
http://www.sciencedirect.com/science?_ob=GatewayURL&_method=citationSearch&_urlVersion=4&_origin=SDVIALERTASCII&_version=1&_uoikey=B6T4Y-511R9PR-6&md5=e3a562f0287663b6568cf239a904b34b

13) The bone remodeling environment is a factor in breast cancer bone metastasis
Review Article, 
Pages 66-70
Li Laine Ooi, Yu Zheng, Kellie Stalgis-Bilinski, Colin R. Dunstan
http://www.sciencedirect.com/science?_ob=GatewayURL&_method=citationSearch&_urlVersion=4&_origin=SDVIALERTASCII&_version=1&_uoikey=B6T4Y-504BH2V-1&md5=2b7525a24d810090961da32a2c9f2bda

14) Bisphosphonates' antitumor activity: An unravelled side of a multifaceted drug class
Review Article, 
Pages 71-79
Philippe Clézardin
http://www.sciencedirect.com/science?_ob=GatewayURL&_method=citationSearch&_urlVersion=4&_origin=SDVIALERTASCII&_version=1&_uoikey=B6T4Y-50KRYSD-1&md5=aa9e73957b8b384a8d60dd534a784f2b

15) Advances in management of bone disease in breast cancer
Review Article, 
Pages 80-87
L. Walkington, R.E. Coleman
http://www.sciencedirect.com/science?_ob=GatewayURL&_method=citationSearch&_urlVersion=4&_origin=SDVIALERTASCII&_version=1&_uoikey=B6T4Y-506RN2S-4&md5=66215b6f4c708492fb8dda7c8ecb600c

16) Treatment and prevention of bone complications from prostate cancer
Review Article, 
Pages 88-95
Richard J. Lee, Philip J. Saylor, Matthew R. Smith
http://www.sciencedirect.com/science?_ob=GatewayURL&_method=citationSearch&_urlVersion=4&_origin=SDVIALERTASCII&_version=1&_uoikey=B6T4Y-506RN2S-5&md5=eefd65fe6023a9265e9caa4d8c5b98d9

17) Clinical development of anti-RANKL therapies for treatment and prevention of bone metastasis
Review Article, 
Pages 96-99
Allan Lipton, Carsten Goessl
http://www.sciencedirect.com/science?_ob=GatewayURL&_method=citationSearch&_urlVersion=4&_origin=SDVIALERTASCII&_version=1&_uoikey=B6T4Y-517BB7J-6&md5=2feda23bd5a6c3c18c6b8689e4d47618

18) Involvement of acidic microenvironment in the pathophysiology of cancer-associated bone pain
Review Article, 
Pages 100-105
Toshiyuki Yoneda, Kenji Hata, Masako Nakanishi, Maho Nagae, Tomotaka Nagayama, Hiroki Wakabayashi, Toshihiko Nishisho, Teruhisa Sakurai, Toru Hiraga
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19) Optical advances in skeletal imaging applied to bone metastases
Review Article, 
Pages 106-114
T.J.A. Snoeks, A. Khmelinskii, B.P.F. Lelieveldt, E.L. Kaijzel, C.W.G.M. Löwik
http://www.sciencedirect.com/science?_ob=GatewayURL&_method=citationSearch&_urlVersion=4&_origin=SDVIALERTASCII&_version=1&_uoikey=B6T4Y-50P9H1X-4&md5=cc8894ae170586c0df6eb5fdcb2d9a53

20) Effects of the bone marrow microenvironment on hematopoietic malignancy
Review Article, 
Pages 115-120
Maria Askmyr, Julie Quach, Louise E. Purton
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21) Tumor–host cell interactions in the bone disease of myeloma
Review Article, 
Pages 121-128
Jessica A. Fowler, Claire M. Edwards, Peter I. Croucher
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22) TGF-β-related mechanisms of bone destruction in multiple myeloma
Review Article, 
Pages 129-134
Toshio Matsumoto, Masahiro Abe
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23) Osteoblast function in myeloma
Review Article, 
Pages 135-140
G. David Roodman
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   Original Articles
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24) Longitudinal live animal micro-CT allows for quantitative analysis of tumor-induced bone destruction
Original Research Article, 
Pages 141-151
Lindsay C. Johnson, Rachelle W. Johnson, Steve A. Munoz, Gregory R. Mundy, Todd E. Peterson, Julie A. Sterling
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25) Neuroblastoma and bone metastases: Clinical significance and prognostic value of Dickkopf 1 plasma levels
Original Research Article, 
Pages 152-159
Donatella Granchi, Maria Valeria Corrias, Alberto Garaventa, Serena Rubina Baglìo, Giuliana Cangemi, Barbara Carlini, Paolo Paolucci, Armando Giunti, Nicola Baldini
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26) Skeletal complications and survival in renal cancer patients with bone metastases
Original Research Article, 
Pages 160-166
Emma Woodward, Satinder Jagdev, Lucy McParland, Katy Clark, Walter Gregory, Alex Newsham, Suzanne Rogerson, Kate Hayward, Peter Selby, Janet Brown
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   CABS 2010 Abstracts
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27) 10th International Conference on Cancer Induced Bone Disease, 22–25 September 2010, Sheffield, UK Abstracts
Page S2
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28) 10th International Conference on Cancer Induced Bone Disease
Page S3
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29) The search for metastatic founder cells: Molecular analysis of disseminated tumour cells from bone marrow of cancer patients
Page S4
C.A. Klein
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30) Reactivation of EMT-inducing transcription factors and cancer development
Pages S4-S5
A. Puisieux
http://www.sciencedirect.com/science?_ob=GatewayURL&_method=citationSearch&_urlVersion=4&_origin=SDVIALERTASCII&_version=1&_uoikey=B6T4Y-51S1SPG-8&md5=5e23f1eff9e02ae42ee5f6cfcd5cd180

31) Modeling the metastatic microenvironment in bone — A single niche for hematopoietic stem cells and cancer provided by skeletal progenitors
Page S5
P. Bianco
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32) Artificial niches that direct stem cell fate
Page S5
M.P. Lutolf
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33) Molecular genetics and risk of metastasis
Pages S5-S6
S.C. Linn
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34) Cancer and the evolution of stem cell fates
Page S6
P.W. Andrews
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35) Quiescent stem cells in intestinal homeostasis, inflammation, and cancer
Page S6
R. Fodde
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36) Controversies in the use of bone targeted agents: Breast cancer prevention
Pages S6-S7
R.T. Chlebowski
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37) Risk of osteonecrosis of the jaw and the use of bone targeted therapies
Page S7
S.L. Ruggiero
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38) Bone marrow endothelial cells as active players in the pathobiology of multiple myeloma
Pages S7-S8
K. Vanderkerken, E. De Bruyne, E. Menu, E. Van Valckenborgh, B. Van Camp
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39) Cell trafficking in multiple myeloma
Page S8
I. Ghobrial
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40) Role of macrophages in tumour progression and therapy
Page S8
C.E. Lewis
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41) Targeting cancer invasion and metastasis
Pages S8-S9
M. Frame, B. Serrels, A. Serrels, M. Canel, E. Sandilands, A. Welman, V. Brunton
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42) Challenges of research on circulating tumour cells in carcinoma patients
Page S9
S. Riethdorf, K. Pantel
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43) New anabolic approaches to treating myeloma bone disease
Page S9
G. Roodman
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44) New therapies for cancer-induced bone disease: Preclinical perspective
Pages S9-S10
T. Guise
http://www.sciencedirect.com/science?_ob=GatewayURL&_method=citationSearch&_urlVersion=4&_origin=SDVIALERTASCII&_version=1&_uoikey=B6T4Y-51S1SPG-S&md5=7297461c0cc4b6352ce8848caece362b

45) New therapies for cancer induced bone disease: Clinical perspective
Page S10
C. Van Poznak
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46) Osteoclast-dependent and -independent effects of RANKL inhibition on tumorigenesis and metastasis
Pages S10-S11
B. Dougall
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47) Involvement of acidic microenvironment in bone pain associated with cancer colonization
Page S11
T. Yoneda, M. Nakanishi, T. Nishisho, H. Wakabayashi, K. Hata
http://www.sciencedirect.com/science?_ob=GatewayURL&_method=citationSearch&_urlVersion=4&_origin=SDVIALERTASCII&_version=1&_uoikey=B6T4Y-51S1SPG-W&md5=52da5951179f0f3a98d2d52724d4a844

48) Lessons to be learned from osteosarcoma
Page S11
D. Heymann
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49) SRC inhibition as an approach to treating tumor-induced bone disease
Pages S11-S12
B.F. Boyce
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50) Human bone marrow-derived mesenchymal stem cell homing to orthotopic breast cancer tumors and promotion of bone metastasis
Page S13
M.R. Reagan*, R. Goldstein, M. Rosenblatt, D.L. Kaplan
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51) TGFβ target gene NEDD9 identified by gene profiling plays a critical role in breast cancer bone metastasis
Page S13
K. Hata*, Y. Morita, M. Nakanishi, T. Nishisyou, T. Yoneda
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52) Identification of plasma biomarkers that predict breast cancer bone metastasis
Pages S13-S14
C.L. Washam*, S.D. Byrum, K. Leitzel, A. Lipton, L.J. Suva
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53) Multiphoton imaging of individual myeloma cells in calvariae: Association of myeloma development with sites of bone turnover
Page S14
A.J. Williams*, M.A. Lawson, O. Alamer, J. Hough, T. Bos, K. Vanderkerken, P.I. Croucher
http://www.sciencedirect.com/science?_ob=GatewayURL&_method=citationSearch&_urlVersion=4&_origin=SDVIALERTASCII&_version=1&_uoikey=B6T4Y-51S1SPG-13&md5=8e29db92adbb44b38e51ee79a8d0f537

54) TGF-β promotion of GLI2 induced pthrp expression is independent of canonical hedgehog signaling
Pages S14-S15
R.W. Johnson*, M.P. Nguyen, S. Padalecki, B. Grubbs, A.R. Merkel, B. Oyajobi, G.R. Mundy, J.A. Sterling
http://www.sciencedirect.com/science?_ob=GatewayURL&_method=citationSearch&_urlVersion=4&_origin=SDVIALERTASCII&_version=1&_uoikey=B6T4Y-51S1SPG-14&md5=edd26cb2be020a71a8325e722cb7446d

55) Denosumab decreases proliferation in giant cell tumor of bone (GCTB)
Page S15
M. Roudier, J.Y. Blay*, S. Chawla, C. Manivel, S.D. Nelson, D. Thomas, L. Woody, R. Soriano, S. Jun, I. Jacobs
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56) Targeting tumour-initiating cells with trail based combination therapy ensures complete and lasting eradication of multiple myeloma tumours in vivo
Page S15
S. Vitovski*, A.D. Chantry, M.A. Lawson, P.I. Croucher
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57) BMP2/7 heterodimeric proteins are potent antagonists of TGFbeta-induced signaling, invasiveness and bone metastasis via inhibition of cancer stem cells
Pages S15-S16
J.T. Buijs, G. van der Horst*, C. van den Hoogen, M. Petersen, H. Cheung, B. de Rooij, R.C.M. Pelger, G. van der Pluijm
http://www.sciencedirect.com/science?_ob=GatewayURL&_method=citationSearch&_urlVersion=4&_origin=SDVIALERTASCII&_version=1&_uoikey=B6T4Y-51S1SPG-17&md5=c0d6f774db968da013cf97c2b39aa31d

58) Denosumab versus zoledronic acid in patients with bone metastases from castration-resistant prostate cancer: Results from a phase 3 randomized trial
Page S16
J. Brown*, M. Carducci, K. Fizazi, M. Smith, R. Damião, L. Karsh, P. Milecki, H. Wang, R. Dansey, C. Goessl
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59) Results of the Medical Research Council (MRC) Myeloma IX study: Effects of zoledronic acid (ZOL) on overall survival (OS) in patients with multiple myeloma (MM)
Pages S16-S17
G.J. Morgan*, F.E. Davies, W.M. Gregory, S.E. Bell, A.J. Szubert, N. Navarro Coy, A.J. Ashcroft, M.T. Drayson, R.G. Owen, G.H. Jackson, J.A. Child
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60) A phase II, randomized, open-label, pilot study to evaluate the safety and the effects on bone resorption of saracatinib (AZD0530) in patients with prostate cancer or breast cancer with metastatic bone disease
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M. Aklilu*, A. Hussain, C.P. Evans, R.A. Hannon, A. Lipton, M. Dimairo, J. Yu, P. Zobel, F.M. Torti, R.D. Finkelman
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61) 62-Month follow-up of ABCSG-12: Adjuvant endocrine therapy, alone or in combination with zoledronic acid, in premenopausal patients with endocrine-responsive early breast cancer
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M. Gnant*, B. Mlineritsch, H. Stoeger, G. Luschin-Ebengreuth, S. Poestlberger, G. Steger, R. Jakesz, C. Singer, H. Eidtmann, R. Greil
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62) The role of macrophage stimulating protein in metastasis of breast cancer to bone
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K. Kretschmann*, S.E. Waltz, A.L. Welm
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63) TIMP-3 up-regulation facilitates osteoclastogenesis and suppresses DC differentiation from monocytes in the bone marrow microenvironment in myeloma
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M. Abe*, M. Hiasa, A. Nakano, S. Nakamura, H. Miki, C. Qu, K. Watanabe, T. Harada, K. Kagawa, K. Takeuchi, S. Ozaki, T. Matsumoto
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64) Incidence and outcomes of osteonecrosis of the jaw from an integrated analysis of three pivotal randomized double-blind, double-dummy phase 3 trials comparing denosumab and zoledronic acid for treatment of bone metastases in advanced cancer patients or myeloma
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J.E. Brown*, C.H. Barrios, I.J. Diel, T. Facon, K. Fizazi, T. Ibrahim, F. Saad, F. Senecal, S.M. Stemmer, A. Stopeck, S. Takahashi, C. Van Poznak, L. Zhou, P. Carriere, A. Daniels, R. Dansey
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65) Laser-capture micro-dissection and gene array analysis to identify new molecules implicated in the development of myeloma bone disease
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C. Buckle*, T. Andersen, J.-M. Delaisse, K. Vanderkerken, P.I. Croucher
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66) Halofuginone reduces bone metastases: TGF-β-dependent and independent effects
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P. Juarez*, K. Mohammad, R. Mckenna, H. Walton, M. Niewolna, J.M. Chirgwin, T.A. Guise
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67) First randomized trial comparing balloon kyphoplasty (BKP) to non-surgical management among cancer patients with vertebral compression fractures
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L. Bastian*, R. Pflügmacher, J.R. Berenson, P. Jarzem, J. Zonder, J.B. Tillman, T. Ashraf, F.D. Vrionis
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68) Patients with bone metastases from solid tumours and poor prognostic features may gain survival benefits from zoledronic acid
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J. Body*, R. Cook, L. Costa, J. Brown, E. Terpos, F. Saad, A. Lipton, R. Coleman
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69) Denosumab versus zoledronic acid (ZA) for the treatment of bone metastases: An integrated analysis of results from 2 randomized, double-blind, phase 3 trials
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A. Lipton*, A. Stopeck, R. von Moos, D. Henry, G. Richardson, G. Rodriguez, H. Bourgeois, C. Ke, S. Jun, R. Dansey
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70) Tumour-secreted lox mediates osteolytic bone metastases prior to metastatic tumour cell colonisation
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H.R. Evans, N. Ab Latif, T.R. Cox, D. Bird, G. Lang, J.T. Erler, A. Gartland*
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71) Adjuvant effect of IV clodronate on delay of bone metastasis in high-risk prostate cancer patientsA prospective study
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P. Rodrigues⁎, F. Hering
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72) Surgical resection of isolated breast cancer recurrence within the sternum
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J. Crighton*, P. Hall, S. Lord, T. Perrin, D. Dodwell
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73) An observational prospective cohort study on the dose effect of zoledronic acid on urinary n-telopeptide levels in metastatic prostate cancer
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L. Drudge-Coates*, C. Brown, R. Sherwood, P.M. Thompson, G.H. Muir
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74) A multicenter prospective study of the risk factors affecting bone mineral density in Korean patients with prostate cancer
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S.I. Jung, S.O. Kim, T.W. Kang*, D.D. Kwon, J.Y. Park, J. Cheon, H.M. Lee, S.J. Hong, H.Y. Choi, S.B. Ryu
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75) Natural history of malignant bone disease in colorectal cancer: Final results of a large Italian “bone metastases” survey
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D. Santini*, S. Barni, M. Tampellini, N. Silvestris, E. Maiello, N. Calipari, T. Ibrahim, V. Catalano, B. Vincenzi, G. Tonini
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76) Efficacy of zoledronic acid in patients with colorectal cancer metastatic to bone
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D. Santini*, F. Loupakis, R. Berardi, G. Badalamenti, L. Addeo, C. Ortega, R. Sabbatini, O. Venditti, V. Virzi, B. Vincenzi, G. Tonini
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77) The Italian cross-sectional survey on the management of bone health in oncology: The ZETA study (On Behalf of ZETA Study Group)
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F. Bertoldo*, D. Santini, I. Cecchini, P. Bartolussi, S. Fregosi
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78) One year effect of anastrozole and risedronate on bone mineral density: First results from the IBIS-II bone sub-study
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S. Singh*, J. Cuzick, G.M. Blake, D. Mesher, R. Patel, J. Truscott, R. Coleman, A. Howell, J. Forbes, R. Eastell
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79) P-9
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80) Relationship between serum N-telopeptide and bone alkaline phosphatase and their diagnostic value in patients with breast cancer and bone metastases
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F. Lumachi⁎, V. Camozzi, G. Luisetto, R. Orlando, S.M.M. Basso, U. Basso, P. Cappelletti
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81) Experimental study of specific antitumor immunity induced by dendritic cell vaccine transfected with tumor cell total RNA in Ewing's sarcoma patients
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H.X. Sang*, Jian Wang, Lin Wang, Zhen Wang, Bin Lu, Yong Fan, W.J. Zhu
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82) Expression of matrix metalloproteinase 1 (MMP1) and dickkopf-1 (DKK1) in bone metastatic tissue (BMT) and in serum of patients with bone metastases (BM) from different solid tumors
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L. Costa, I. Luís*, I. Alho, A. Fernandes, S. Casimiro, B.H. Lee, E.A. Gangolli, M. Motwani, L. Wang, V. Modur
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83) Reduced risk of breast cancer in postmenopausal women with osteoporosis. Preliminary results in a high risk metropolitan area: A case–control study
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F. Lumachi*, V. Tombolan, V. Camozzi, G. Luisetto, S.M.M. Basso, A. Brunello, U. Basso
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84) Exploiting the tear proteome for the diagnosis of breast cancer
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C. Washam, S. Byrum, S. Bhattacharyya, V.S. Klimberg, L.J. Suva*
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85) Bone mineral density and bone remodelling markers osteocalcin and alkaline phosphatase in patients with Stage IV breast cancer
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F. Lumachi*, V. Camozzi, G. Luisetto, R. Orlando, S.M.M. Basso, A. Brunello, U. Basso
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86) Can bone biopsies be used to confirm metastatic disease recurrence and receptor status in breast cancer patients?
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E. Amir*, N. Miller, W. Geddie, H. Maung, O.C. Freedman, M. Oldfield, J. Napolskikh, F. Kassam, M. Clemons
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87) Hypocalcemia in multiple myeloma secondary to unrecognised vitamin D deficiency: A case report
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I. Ramasamy*
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88) Rapid pain reduction following loading-dose ibandronate in bone metastases
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A.A. Kurth*, A. Müller, B. Habermann, C. Eberhardt
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89) Prospective clinical trial to evaluate the value of radiofrequence ablation and cement augmentation of spinal metastases
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D. Proschek, B. Habermann, M. Tonak, P. Proschek, A.A. Kurth*
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90) P-20
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91) Metastatic bone disease of the mandible — A case report
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B. Drozdzowska*, A. Raczkowska-Siostrzonek, R. Koszowski
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92) Bone health in breast cancer survivors following adjuvant bisphosphonate therapy: AZURE quantitative bone scan sub-study
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E.J. Woodward*, J.E. Brown, M.C. Barnfield, J. Taylor, G.M. Blake, I. Fogelman, L.A. Turner, H. Thorpe, D. Dodwell, J.K. Joffe, R.E. Coleman
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93) Safety of zoledronic acid and incidence of osteonecrosis of the jaw (ONJ) during adjuvant therapy in a randomised phase III trial (AZURE–BIG 01–04) for women with stage II/III breast cancer
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R.E. Coleman, E.J. Woodward*, J.E. Brown, D. Cameron, R. Bell, D. Dodwell, M. Keane, M. Gil, C. Davies, R. Burkinshaw, S.J. Houston, R.J. Grieve, P.J. Barrett-Lee, H. Thorpe
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94) Gene expression in prostate cancer bone metastases in relation to expression of the androgen receptor and one of its constitutively active variants
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E. Hörnberg*, A. Bergh, A. Widmark, H. Antti, P. Wikström
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95) Analysis of the various components of bone turnover in postmenopausal breast cancer patients with bone metastases
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F. Bertoldo*, S. Pancheri, S. Boldini, S. Zenari, A. Avesani
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96) The addition of zoledronic acid to combination chemotherapy decreases circulating serum levels of vascular endothelial growth factor (VEGF) in early breast cancer
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M.C. Winter*, A. Evans, I. Holen, R.E. Coleman
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97) Comparing early intervention with zoledronic acid to no bisphosphonate (BP) therapy in patients with metastatic prostate cancer to bone: A study of the US Veterans Affairs (VA) population
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E.Q. Wu*, A. Guo, L. Shi, M. Lu, A.P. Yu, H. Sharma, C.P.S. Fan, N. Vander Velde
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98) The role of pamidronate in palliative treatment for bone metastases in squamous cell carcinoma of head and neck
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W. Rolski*, W. Leppert
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99) P-29
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100) P-30
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101) Glutamate release in bone metastasis
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E.P. Seidlitz*, M.K. Sharma, G. Singh
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102) The chemokine receptor CXCR7 is highly expressed in bone metastatic lesions of human prostate cancer and mediates tumor cell growth and invasiveness in preclinical models
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G.L. Gravina, M. Angelini, R. Montironi, L. Ventura, F. Marampon, G. Pratesi, M. Tortoreto, V. Tombolini, C. Festuccia*
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103) CCN3 impairs osteoblasts and stimulates osteoclast differentiation to favor breast cancer metastasis to bone
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E. Amir*, V. Ouellet, A. Mourskaia, K. Tiedemann, J. Fong, D. Tran-Tanh, M. Clemons, B. Perbal, S. Komorova, P. Siegel
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104) P-34
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105) Activation of the osteopontin gene, a bone metastatic signature, by transcription factor ERG in prostatic cancer cells
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S. Flajollet, T.V. Tian, A. Flourens, N. Tomavo, E. Bonnelye, X. Leroy, M. Duterque-Coquillaud*
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106) Towards biomarkers of bone-metastasis using cellular proteomics
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J.A. Westbrook*, J. Peng, D.A. Cairns, P.D. Ottewell, I. Holen, R.E. Coleman, P.J. Selby, R.E. Banks, J.E. Brown
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107) A study of the role of twist in migration and invasion of breast cancer cells
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S. Li, S.E. Kendall, R. Raices, C. Tran, Z. Liu, M. Covarrubias, V.K. Leigh, S.D. Flanagan, C.A. Glackin*
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108) Camp-response-element-binding protein positively regulates breast cancer metastasis and subsequent bone destruction
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J. Son, J.H. Lee, H.N. Kim, H. Ha, Z.H. Lee*
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109) Osteoprotegerin inhibitits bone resorption and prevents tumor development in a xenogenic model of Ewing's sarcoma by inhibiting RANKL produced by tumor cells
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G. Picarda, E. Matous, S. Hervouet, F. Lamoureux, V. Trichet, D. Heymann, F. Rédini
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110) RANKL silencing by siRNA improves therapeutic response of primary osteosarcoma to conventional chemotherapy
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J. Rousseau, V. Escriou, F. Lamoureux, R. Brion, S. Battaglia, D. Scherman, D. Heymann, F. Rédini*, V. Trichet
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111) Osteolytic versus mixed osteolytic/osteoblastic vertebral metastasis: Comparison of bone structural and remodelling properties in two preclinical rat models
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L. Wise-Milestone*, M.K. Akens, N.K. Thudi, T.J. Rosol, M.D. Grynpas, A. Yee, B. Wilson, C.M. Whyne
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112) Local treatment of mixed osteolytic/osteoblastic spinal metastases: Is photodynamic therapy effective?
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L. Wise-Milestone*, M.K. Akens, N.K. Thudi, T.J. Rosol, M.D. Grynpas, A. Yee, B. Wilson, C.M. Whyne
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113) Influence of pre-treatment with bisphosphonate on the outcome of photodynamic therapy on breast cancer metastases in murine vertebrae
Pages S35-S36
M.K. Akens*, L. Wise-Milestone, E. Won, B.C. Wilson, A.J.M. Yee, C.M. Whyne
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114) Direct anti-cancer effect of oncostatin M on chondrosarcoma
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E. David, P. Guihard, B. Brounais, A. Riet, C. Charrier, S. Battaglia, S. Ponsolle, R. Le Bot, C.D. Richards, D. Heymann, F. Redini, F. Blanchard*
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115) Controlled skeletal tissue ablation using novel navigational radio frequence ablation device
Page S36
A.A. Kurth*, D. Proschek, A. Germain, R. Poser
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116) The novel anti-resorptive agent reveromycin A ameliorates bone destruction and tumor growth in myeloma
Pages S36-S37
K. Watanabe*, M. Abe, C. Qu, M. Kawatani, M. Hiasa, A. Nakano, T. Harada, S. Nakamura, H. Miki, K. Kagawa, K. Takeuchi, H. Ozaki, H. Osada, E. Tanaka, T. Matsumoto
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117) Mechanisms of osteoblast supression in multiple myeolma
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D. Kassen*, N. Rabin, D. Lath, P.I. Croucher, K. Yong
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118) Targeting TCF transcriptional activity rescues syndecan-2 expression and re-sensitizes human osteosarcoma cells and mouse bone tumours to doxorubicin
Pages S37-S38
F.X. Dieudonné*, A. Marion, P.J. Marie, D. Modrowski
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119) Abnormal expression of calpain-6 due to endothelin-1/NFκB signalling contributes to cell survival and chemoresistance in osteosarcoma cells
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A. Marion*, F.X. Dieudonné, A. Patiño, F. Lecanda, P.J. Marie, D. Modrowski
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120) P-50
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121) Novel application of aptamer selection (pheno-SELEX) to target the invasive phenotype successfully creates anti-metastatic aptamers
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G. Shelley*, X. Zhang, J. Keller, E. Keller
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122) Accelerated osteolytic metastasis in B16-inoculated mice pre-exposed to non-skeletal focal irradiation in the abdomen
Pages S38-S39
Q. Fu, L. Hennings, D. Gaddy, P.M. Corry, D. Jia*
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123) Skeletal rigidity enhances TGF-Β effects on cancer cell expression of osteolytic factors
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N.S. Ruppender, J.A. Sterling*, T.J. Martin, G.R. Mundy, S.A. Guelcher
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124) Examination of the mechanism(s) of cancer-induced bone pain in animal models
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R. Ungard*, E. Seidlitz, P. De Ciantis, K. Yashpal, J.L. Henry, G. Singh
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125) Interaction of autotaxin with breast cancer cell integrins might contribute to lysophosphatidic acid-mediated bone metastases
Pages S39-S40
M. David, R. Leblanc, B. Deux, C.M. Serre, J. Ribeiro, P. Clézardin, O. Peyruchaud*
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126) A direct contact model system to study tumor cell–bone cell interactions in prostate cancer bone metastases
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A. Nordstrand*, P. Wikström, U.H. Lerner, A. Widmark
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127) Comparison of optical, radiography and micro-Computed Tomography imaging methods for the analysis of bone metastases in a murine model
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S. Tiwari*, C. Schem, A.C. Lorenzen, O. Kayser, C. Graeff, J. Peña, R.P. Marshall, W. Jonat, C.C. Glüer
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128) Changes in osteoblast and osteoclast number rely on direct contact with breast cancer cells — Evidence from a longitudinal study of bone metastasis
Pages S40-S41
H.K. Brown*, P.D. Ottewell, C.A. Evans, I. Holen
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129) Molecular characterization of the stromal response to osteoblastic bone metastasis by tissue-compartment specific transcriptional profiling
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B. Ozdemir*, C. Secondini, A. Wetterwald, R. Schwaninger, W. Raffelsberger, O. Poch, M. Delorenzi, G. van der Pluijm, G.N. Thalmann, M.G. Cecchini
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130) Combination vs single agent treatment: The effects of zoledronic acid+/−doxorubicin on breast tumour growth in bone prior to development of osteolytic bone disease
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H.K. Brown*, P.D. Ottewell, C.A. Evans, R.E. Coleman, I. Holen
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131) CpG-ODN inhibits Smad-dependent BMP signaling; Effects on myeloma cell apoptosis and in vitro osteoblastogenesis
Pages S41-S42
N. Nørgaard, T. Holien, S. Jönsson, H. Hella, T. Espevik, A. Sundan, T. Standal*
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132) First evidence for anti-tumour effects of doxorubicin and zoledronic acid from an immunocompetent mouse model
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P.D. Ottewell*, H. Brown, C.A. Evans, N.S. Wind, N.J. Brown, R.E. Coleman, I. Holen
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133) The causal role of the BMP signalling antagonist noggin in suppressing bone formation in osteolytic bone metastasis
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C. Secondini*, A. Wetterwald, R. Schwaninger, G.N. Thalmann, M.G. Cecchini
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134) An exopolysaccharide produced by alteromonas infernus reduces lung metastasis and prolongs survival rate of osteosarcoma-bearing mice
Pages S42-S43
C. Ruiz Velasco*, S. Colliec-Jouault, C. Sinquin, D. Heymann, M. Padrines
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135) MNNG-HOS osteosarcoma growth is enhanced by human fat and adipose-derived mesenchymal stem cells: Implication in reconstructive surgery following tumor treatment
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L. Bourdais, P. Perrot, D. Duteille, S. Hervouet, J. Chesneau, J. Amiaud, G. Picarda, G. De Pigneux, F. Redini, D. Heymann*, V. Trichet
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136) The novel and selective insulin-like growth factor-1 receptor kinase inhibitor PQIP suppresses bone cell function and osteoclast-breast cancer cell cross-talk in vitro
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J.G. Logan*, E. Landao-Bassonga, V.G. Brunton, A.I. Idris
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137) Inhibition of Dickkopf-1 (DKK-1) delays prostate cancer growth in vivo through induction of P21CIP-1
Pages S43-S44
C.L. Hall*, H. Zhang, S. Baile, S. Kuhstoss, E.T. Keller
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138) Peripheral cannabinoid type 2 receptor regulates osteoclast formation, MDA-MB-231 breast cancer cell migration and bone marrow/tumour cell interaction via PI3 kinase/AKT and P38 pathways
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A. Sophocleous*, A. Mackintosh, E. Landao-Bassonga, S.H. Ralston, A.I. Idris
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139) Identification of hydrogen sulfide releasing compounds as novel antiresorptive and antitumour agents
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A.I. Idris*, J. Frantzias, P. Mollat, A. Sparatore, P. Del Soldato, S.H. Ralston
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140) Does differential expression of CD151 affect the ability of beast cancer cells to establish tumours in bone?
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N.S. Wind*, H. Brown, P.D. Ottewell, R. Sadej, H. Romanska, F. Berditchevski, I. Holen
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141) GLPG0187 inhibits progression of established bone metastasis and achieves maximum efficacy when combined with standard-of-care metastatic breast cancer treatments
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P. Clément-Lacroix, E. Berrocal, B. Heckmann, P. Wigerinck, G. Lorenzon, P. Pujuguet*
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142) The homing of prostate cancer to bone in vivo is modulated by Zoledronic acid
Pages S45-S46
K.J. Reeves*, M.G. Cecchini, G. van der Pluijm, C.L. Eaton, F.C. Hamdy, N.J. Brown
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143) Probing the relationship between breast cancer stem cells and bone metastasis
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K. Tan-Allen, J.E. Gilmore, J. Foley
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144) Zoledronic acid induces IPP accumulation and release from human cancer cells, which activates Vγ9Vδ2 T cell-differentiation and migration in vitro and mediates Vγ9Vδ2 T cell-induced cancer cell death in vivo
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I. Benzaid*, H. Monkkonen, V. Stresing, E. Bonnelye, J. Green, J. Monkkonen, P. Clézardin
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145) Spontaneous fusion between prostate cancer cells: A driver for development of tumor heterogeneity and growth in bone
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G. Pesce*, A. Glen, J. Lippitt, A. Fowles, I. Rehman, C.L. Eaton
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146) Corning osteo assay surface for the study of bone resorption
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A.F. Faruqi*, H. Rao, J. Causer, J. Beltzer
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147) A new Β Crosslaps® (CTX-I) assay on the IDS-ISYS automated analyser
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Z. Seres*, S. Middlemist, C. Dixon, D. Laurie, A.K. Barnes, M. Garrity
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148) Twist 1 expression in an osteotropic breast cancer cell line promotes bone metastasis formation in mouse
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M. Croset*, D. Goëhrig, E. Bonnelye, S. Ansieau, A. Puisieux, P. Clézardin
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149) The role of parathyroid hormone-related protein in giant cell tumour of bone
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R.W. Cowan*, G. Singh, M. Ghert
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150) Osteocyte-derived FGF23 activates EGR-1 signaling in prostate cancer cells: A new vicious cycle in bone metastases
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P. Fournier, D. Edwards, K. White, J.M. Chirgwin*
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151) Inhibition of discoidin domain receptor-1 (DDR1) impairs tumor-induced osteoclastogenesis preventing bone metastatic homing and colonization
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K. Valencia*, C. Zandueta, C. Ormazábal, D. Luis-Ravelo, I. Antón, S. Martínez, F. Lecanda
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152) P-82
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153) A method to follow tumor growth and tumor induced bone loss simultaneously over time, in vivo, using whole body bioluminescence fluorescence imaging
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T.J.A. Snoeks*, A. Khmelinskii, I. Que, B. Lelieveldt, E.L. Kaijzel, C.W.G.M. Löwik
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154) RAP-661 treatment, an ALK3 (BMPRIA) antagonist, decreases rankl and regulates osteoclastogenesis
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N. Solban*, M. Cornwall-Brady, Y. Kawamoto, K.W. Underwood, R. Kumar, J. Seehra, E. Canalis, R.S. Pearsall
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155) The role of fibronectin originating from different sources on breast cancer metastasis development and bone remodeling
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A. von Au, M. Vasel, M. Cecchini, I.A. Nakchbandi*
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156) Development of a targeted strategy for enrichment and detection of calcium-binding proteins as potential biomarkers for bone metastases in breast cancer
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S.L. Wood*, J.A. Westbrook, J. Peng, P.J. Selby, J.E. Brown
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157) Cathepsin K inhibitors for the treatment of bone metastasis
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E. Lindström*, L. Vrang, S. Sedig, Y. Terelius, B.-L. Sahlberg, K. Wikström, B. Samuelsson, T. Chambers, U. Grabowska
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158) P-88
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159) Evaluation of a novel bone targeted aracytidine therapy in dogs with spontaneous osteosarcoma
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S. Zinnen*, D. Thamm, D. Vail, T. Fan, A. Karpeisky
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160) P-90
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161) Breast cancer cell epidermal growth factor receptor signaling and osteolysis
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N.K. Nickerson*, J.L. Gilmore, A. Robling, J. Foley
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162) P-92
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164) Molecular beacon-guided surgical resection of primary spinal neoplasms
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167) High-dose antioxidants as potential anti-osteolytic and palliative therapies for breast cancer bone metastasis
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169) Effect of VEGF inhibitor PF-00337219 and FAK/PYK2 inhibitor PF-562,271 on intratibial growth of breast cancer cells in nude rats and mice
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170) Calcium metabolism in castration-resistant prostate cancer patients: Development of a quantitative urinary assay for extent of bone metastasis
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171) Immune interplay between osteolytic disease and bone metastasis
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