<p dir="ltr">А с ксарелто и пр.?</p>
<div class="gmail_extra"><br><div class="gmail_quote">1 нояб. 2016 г. 8:53 пользователь "Alexander Chelnokov" <<a href="mailto:orthoforum@weborto.net">orthoforum@weborto.net</a>> написал:<br type="attribution"><blockquote class="gmail_quote" style="margin:0 0 0 .8ex;border-left:1px #ccc solid;padding-left:1ex">Аспирин опять лучше варфарина для профилактики тромбоэмболических<br>
осложнений... Не пора ли пересматривать клинические рекомендации?<br>
<br>
J Arthroplasty. 2016 Oct;31(10):2237-40. doi:<br>
10.1016/j.arth.2016.03.031. Epub 2016 Mar 30.<br>
<br>
Aspirin Can Be Used as Prophylaxis for Prevention of Venous<br>
Thromboembolism After Revision Hip and Knee Arthroplasty.<br>
<br>
Deirmengian GK1, Heller S1, Smith EB1, Maltenfort M1, Chen AF1, Parvizi J1.<br>
<br>
Author information<br>
<br>
1Rothman Institute, Thomas Jefferson University Hospital, Philadelphia, PA.<br>
<br>
Abstract<br>
<br>
BACKGROUND:<br>
<br>
The optimal prophylaxis for prevention of venous thromboembolic events<br>
(VTEs) after revision total joint arthroplasty (TJA) remains unknown.<br>
The objective of this study was to evaluate whether aspirin, known to be<br>
effective for prevention of VTEs after primary arthroplasty, is also<br>
effective after revision TJA.<br>
<br>
<br>
<br>
METHODS:<br>
<br>
We studied 2997 consecutive patients who underwent revision TJA between<br>
2005 and 2013 and were treated with intermittent pneumatic compression<br>
devices and either aspirin (534 patients) or warfarin (2463 patients)<br>
for VTE prophylaxis. Pertinent data including the incidence of<br>
symptomatic VTEs, bleeding events, infection, and mortality were<br>
retrieved from our prospectively collected database.<br>
<br>
<br>
<br>
RESULTS:<br>
<br>
The incidence of symptomatic VTEs was significantly higher in the<br>
warfarin group at 1.75% (43 of 2463) compared with 0.56% (3 of 534) in<br>
the aspirin group (odds ratio: 3.2; 95% CI: 1.03-16.3; P = .03). There<br>
was a higher rate of bleeding events with administration of warfarin<br>
(1.5%) compared with aspirin (0.4%; P = .02; odds ratio: 4.1; 95% CI:<br>
1.2-34.0). The rate of surgical site infection was similar between the<br>
aspirin group and the warfarin group (1.61% and 1.70%, respectively).<br>
<br>
<br>
<br>
CONCLUSION:<br>
<br>
Administration of aspirin as prophylaxis against VTEs after revision<br>
arthroplasty may be a viable option as it appears to be more effective<br>
than warfarin in prevention of symptomatic VTEs and is associated with a<br>
lower rate of complications.<br>
<br>
<br>
<br>
PMID: 27118182 DOI: 10.1016/j.arth.2016.03.031<br>
<br>
<a href="https://www.ncbi.nlm.nih.gov/pubmed/27118182" rel="noreferrer" target="_blank">https://www.ncbi.nlm.nih.gov/<wbr>pubmed/27118182</a><br>
<br>
Alexander Chelnokov<br>
<br>
<br>
<br>
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</blockquote></div></div>